GCMS vs HPLC. What is the difference?
GCMS (Gas Chromatography Mass Spectrometry) and HPLC (High Performance Liquid Chromatography) are commonly used to test the quality of essential oil. Many chemical compounds, including metabolites can be analyzed by GCMS and HPLC, because they have similar basic principle of compound separation, identification, and quantification . However, not all the metabolite compounds are easily separated by GCMS or HPLC. Understanding when to use GCMS or HPLC is very important.